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KMID : 0358419940370112227
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Korean Journal of Obstetrics and Gynecology
1994 Volume.37 No. 11 p.2227 ~ p.2232
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The Efficacy of Solco Trichovac Vaccine in the Treatment of Trichomoniasis and Non-specific Vaginitis
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장석일
이근우/고영미/한상균/이준모/남궁성은/김승조
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Abstract
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Solco Trichovac is a vacine of Lactobacillus acidophilus developed for theating trichomoniasis. The efficacy of the vaccine is reportedly clue to cross reacting antibody being produced in people immunized with the lactobacillus bacteria.
We present a analysis of 22 patients with trichomoniasis and 9 patients with non-specific vaginitis who visited out department between Jul. 1992 and Oct. 1993 after vaccination with Solco Trichovac(r).
Immunological and cytological examinations were used to evaluate the efficacy of treatment in trichomoniasis and non-specific vaginitis and following results were obtained:
1. The specific serum agglutination titers in trichomoniasis increased from a basal mean level 1:35 to 1:161after 1 month. 1:255 after 2 months and 1:269 after 3 months.
2. The specific serum agglutination titers in non-specific vaginitis increased from a basal mean level of 1:48 to 1:112 after 1 month, 1:167 after 2 months and 1:151 after 3 months.
3. The specific serum agglutination titers in non-specific vaginitis was relatively lower than in trichomoniasis.
4. The identification rate of trichomonas vaginalis decreased from 36.4%(8/22) after 1 months, to 18.2%(4/22) after 2 months and 13.6%(3/22) after 3 months.
5. The prevalence of demonstrated Clue cell in non-specific vaginitis decreased from 33.4%(3/9) after 1 month, to 22.2%(2/9) after 2 months and 11.1%(1/9) after 3 months.
6. The initial mean pH value of 5.62 before the vaccination in non-specific vaginitis also dropped to 4.96 after 1 month 4.81 after 2 months, and 4.61 after 3 months.
The seresults now appear to be attributable to treat the trichomonas vaginalis infection and non-specific vaginitis, but further studies are necessary to fully evaluate the occurrence of reinfec-tion or relapse over a longer period of time.
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